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  5. Tocris Bioscience™ I-BET 151 hydrochloride

Tocris Bioscience™ I-BET 151 hydrochloride
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Catalog No. 465010
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Catalog No. Quantity
46-501-0 10 mg
46-505-0 50 mg
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Catalog No. 46-501-0 Supplier Tocris Bioscience™ Supplier No. 4650/10
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Description

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes.

Chemical Identifiers

Molecular Formula C23H21N5O3

Specifications

Quantity 10 mg
Formula Weight 451.9
Purity >98%
Chemical Name or Material I-BET 151 hydrochloride

Safety and Handling

Recommended Storage Store at -20°C
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