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  7. I-BET 151 hydrochloride, Tocris Bioscience™ 

I-BET 151 hydrochloride, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
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C23H21N5O3
7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one hydrochloride
This item is not returnable. View return policy
C23H21N5O3
7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one hydrochloride

Description

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes.

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Quantity 10mg
Formula Weight 451.9
Percent Purity >98%
Chemical Name or Material I-BET 151 hydrochloride

Safety and Handling

Recommended Storage : Store at -20°C