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Tocris Bioscience™ I-BET 151 hydrochloride

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Quantity:
10 mg
50 mg
Description
BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes.
Specifications
Specifications
Quantity | 10 mg |
Formula Weight | 451.9 |
Purity | >98% |
Chemical Name or Material | I-BET 151 hydrochloride |
Safety and Handling
Recommended Storage | Store at -20°C |
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