I kappa B-beta Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-1092	100 μL

Catalog No. 50-156-1092 Supplier Bethyl Laboratories, Inc Supplier No. A301828A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.

Specifications

• Antigen: I kappa B-beta
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/ml
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: NFKBIB
• Gene Accession No.: Q15653
• Gene Alias: ikappaBbeta, I-kappa-B-beta, IKBB, ikB-B, ikB-beta, NF-kappa-B inhibitor beta, NF-kappa-BIB, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta, thyroid receptor-interacting protein 9, TR-interacting protein 9, TRIP9, TRIP-9
• Gene Symbols: NFKBIB
• Host Species: Rabbit
• Immunogen: Between 306 and 356
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4793
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG