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Invitrogen™ ICAM-1 Monoclonal Antibody (3E2B)
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Catalog No. ENMA5405
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500 μg
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Catalog No. Quantity
ENMA5405 500 μg
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Catalog No. ENMA5405 Supplier Invitrogen™ Supplier No. MA5405
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Description

Armenian Hamster Monoclonal Antibody

MA5405 targets CD54 in WB, ELISA, FACS, IA, IHC, ICC/IF and Neu applications and shows reactivity with mouse samples. The MA5405 immunogen is mouse ICAM-1 (CD54). MA5405 detects CD54 which has a predicted molecular weight of approximately 56 kDa. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ICAM-1
Applications ELISA, Flow Cytometry, Inhibition Assays, Immunohistochemistry (Paraffin), Neutralization, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3E2B
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ICAM1
Gene Accession No. P13597
Gene Alias BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells
Gene Symbols ICAM1
Host Species Armenian Hamster
Immunogen Mouse ICAM-1 (CD54).
Purification Method Protein G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15894
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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