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Invitrogen™ ICAM-1 Monoclonal Antibody (D3.6)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA112140
Description
ICAM-1 Monoclonal Antibody for Flow
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Specifications
ICAM-1 | |
Monoclonal | |
Unconjugated | |
ICAM1 | |
BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells | |
Mouse | |
Protein A/G | |
RUO | |
3383 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Flow Cytometry | |
D3.6 | |
PBS with 0.08% sodium azide | |
P05362 | |
ICAM1 | |
MHC class II-negative human b-lymphoblastoid cell line 6.16c13. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
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