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Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-04)
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Catalog No. 01675003
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100 μg
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Catalog No. Quantity
01-675-003 100 μg
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Catalog No. 01-675-003 Supplier Invitrogen™ Supplier No. MA119030
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Description

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1). Functional Application: Blocking.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
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Specifications

Antigen ICAM-3
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone MEM-04
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene ICAM3
Gene Accession No. P32942
Gene Alias CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Gene Symbols ICAM3
Host Species Mouse
Immunogen Leukocytes from a patient suffering from LGL type leukemia.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3385
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

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