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Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-171)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119191

Catalog No. 01-675-955


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Description

Description

This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ICAM-3
Monoclonal
1.0 mg/mL
PBS with 15mM sodium azide; pH 7.4
P32942
ICAM3
Human granulocytes.
100 μg
Primary
Human
Antibody
IgG1
Flow Cytometry, Immunoprecipitation
MEM-171
Unconjugated
ICAM3
CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Mouse
Protein A
RUO
3385
4°C, do not freeze
Liquid
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