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Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-171)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119191
Description
This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Specifications
ICAM-3 | |
Monoclonal | |
1.0 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P32942 | |
ICAM3 | |
Human granulocytes. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunoprecipitation | |
MEM-171 | |
Unconjugated | |
ICAM3 | |
CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3 | |
Mouse | |
Protein A | |
RUO | |
3385 | |
4°C, do not freeze | |
Liquid |
Safety and Handling
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