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Invitrogen™ Idarucizumab Humanized Recombinant Human Monoclonal Antibody
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Catalog No. PIMA541998
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100 μg
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PIMA541998 100 μg
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Catalog No. PIMA541998 Supplier Invitrogen™ Supplier No. MA541998
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Description

Human Recombinant Monoclonal Antibody

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, especially when given to patients at increased risk (elderly, chronic kidney disease, concomitant NSAID or warfarin use, etc.). Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran. Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199.
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Specifications

Antigen Idarucizumab Humanized
Applications ELISA, SDS-Page
Classification Recombinant Monoclonal
Concentration 2.53 mg/mL
Conjugate Unconjugated
Formulation 30mM histidine, PBS with 10% sucrose, 60ppm Tween 80 and no preservative; pH 6.0
Gene Alias aDabi-Fab; dabigatran; dabigatran etexilate mesylate
Host Species Human
Immunogen Pradaxa (Dabigatran Etexilate Mesylate) dabigatran etexilate mesylate.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 F(ab) κ
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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