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Invitrogen™ IDH2 Monoclonal Antibody (GT673)
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Catalog No. PIMA517271
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100 μL
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PIMA517271 100 μL
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Catalog No. PIMA517271 Supplier Invitrogen™ Supplier No. MA517271
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Description

Mouse Monoclonal Antibody

Recommended positive controls: HepG2, Jurkat, Raji, K562, THP-1, NCI-H929, mouse brain, rat brain, DDDDK-tagged IDH2-transfected 293T. Predicted reactivity: Mouse (97%), Rat (96%), Zebrafish (89%), Xenopus laevis (91%), Pig (96%), Chicken (95%), Rhesus Monkey (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NADas the electron acceptor and the other NADP. Five isocitrate dehydrogenases have been reported: three NAD-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDH2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT673
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Idh2
Gene Accession No. P48735, P54071, P56574
Gene Alias D2HGA2; E430004F23; ICD-M; IDH; Idh2; Idh-2; IDHM; IDP; IDPM; isocitrate dehydrogenase (NADP(+)) 2; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; NADP+-specific ICDH; NADP+-specific isocitrate dehydrogenase; NADPH-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
Gene Symbols Idh2
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human IDH2. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 269951, 3418, 361596
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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