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Invitrogen™ IDO Recombinant Rabbit Monoclonal Antibody (7H8L17)

Catalog No. 740141RXS
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200 μL
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74-014-1RXS 40 μL
74-014-1R 200 μL
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Catalog No. 74-014-1RXS Supplier Invitrogen™ Supplier No. 740141RXS
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Description

Rabbit Recombinant Monoclonal Antibody

This is an engineered recombinant antibody that was developed to provide superior sensitivity without changing the paratope. Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IDO
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Recombinant Monoclonal
Clone 7H8L17
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene Ido1
Gene Accession No. P14902
Gene Alias EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols Ido1
Host Species Rabbit
Immunogen Protein corresponding to human IDO (aa1-aa403).
Purification Method Protein A
Quantity 40 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3620
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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