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Invitrogen™ IFI16 Polyclonal Antibody
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Catalog No. PIPA5101600
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100 μL
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PIPA5101600 100 μL
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Catalog No. PIPA5101600 Supplier Invitrogen™ Supplier No. PA5101600
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IFI16.

IFI16 (gamma-inteferon-inducible protein 16) binds double-stranded DNA. It binds preferentially to supercoiled DNA and cruciform DNA structures. It seems to be involved in transcriptional regulation and as a transcriptional repressor. IFI16 may have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. It controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. IFI16 is also involved in innate immune response by recognizing viral dsDNA in the cytosol and nucleus. After binding to viral DNA in the cytoplasm, IFI16 recruits TMEM173/STING and mediates the induction of IFN-beta. It is necessary to activate the IFR3 signaling cascade suring human herpes simplex virus 1 infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibiton of viral immediate-early gene expression and replication. IFI16 is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFI16
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IFI16
Gene Accession No. Q16666
Gene Alias gamma-interferon-inducible protein 16; IFI 16C; IFI16; Ifi-16; IFNGIP1; interferon gamma inducible protein 16; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; PYHIN2
Gene Symbols IFI16
Host Species Rabbit
Immunogen A synthesized peptide derived from human IFI16(Accession Q16666), corresponding to amino acid residues E739-F785.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3428
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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