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Invitrogen™ IFI16 Recombinant Rabbit Monoclonal Antibody (8H37L1)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ 703147

Description
This antibody is predicted to react with Mouse, Rat, Bovine.
IFI16 (gamma-inteferon-inducible protein 16) binds double-stranded DNA. It binds preferentially to supercoiled DNA and cruciform DNA structures. It seems to be involved in transcriptional regulation and as a transcriptional repressor. IFI16 may have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. It controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. IFI16 is also involved in innate immune response by recognizing viral dsDNA in the cytosol and nucleus. After binding to viral DNA in the cytoplasm, IFI16 recruits TMEM173/STING and mediates the induction of IFN-beta. It is necessary to activate the IFR3 signaling cascade suring human herpes simplex virus 1 infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibiton of viral immediate-early gene expression and replication. IFI16 is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Specifications
IFI16 | |
Recombinant Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q16666 | |
IFI16 | |
Protein corresponding to human IFI16 [1) aa571-aa766 2) aa446-aa571]. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
Western Blot, Immunocytochemistry | |
8H37L1 | |
Unconjugated | |
IFI16 | |
gamma-interferon-inducible protein 16; IFI 16C; IFI16; Ifi-16; IFNGIP1; interferon gamma inducible protein 16; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; PYHIN2 | |
Rabbit | |
Protein A | |
RUO | |
3428 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
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