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Invitrogen™ IFIT1 Monoclonal Antibody (OTI3G8)
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Catalog No. PIMA525050
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100 μL
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PIMA525050 100 μL
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Catalog No. PIMA525050 Supplier Invitrogen™ Supplier No. MA525050
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Description

Mouse Monoclonal Antibody

IFIT1 Monoclonal Antibody for Flow, ICC/IF, IHC (P), Western Blot

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFIT1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3G8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene IFIT1
Gene Accession No. P09914
Gene Alias C56; G10P1; Garg16; GARG-16; glucocorticoid-attenuated response gene 16 product; glucocorticoid-attenuated response gene 16 protein; Ifi56; IFI-56; IFI-56K; IFIT1; IFIT-1; IFNAI1; interferon induced protein with tetratricopeptide repeats 1; interferon, alpha-inducible protein (MW 56kD); interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; interferon-induced protein with tetratricopeptide repeats 1-like protein; interferon-inducible mRNA 561; Isg56; P56; RNM561
Gene Symbols IFIT1
Host Species Mouse
Immunogen Full length human recombinant protein of IFIT1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3434
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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