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IFIT1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 232471AP150UL

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Catalog No. 50-173-4028


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Description

Description

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2′-O-methylation of the 5′ cap and bear a 5′-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2′-O-methylase for their mRNAs or by stealing host cap containing the 2′-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Specifications

Specifications

IFIT1
Polyclonal
Unconjugated
IFIT1
G10P1, GARG 16, IFI 56, IFI 56K, IFI56, IFIT 1, IFIT1, IFNAI1, ISG56, RNM561
Rabbit
Antigen Affinity Chromatography
RUO
15957, 3434, 56824
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.25 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P09914, Q64282
IFIT1
IFIT1 Fusion Protein Ag19691
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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