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Invitrogen™ Mouse IgD Monoclonal Antibody (10.4.22), Functional Grade, eBioscience™

Catalog No. 501128593
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500 μg
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Catalog No. Quantity
50-112-8593 500 μg
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Catalog No. 50-112-8593 Supplier Invitrogen™ Supplier No. 16592485
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Description

Mouse Monoclonal Antibody

Description: This 10.4.22 monoclonal antibody reacts with the a allotype of mouse IgD, which is expressed by mature peripheral B cells. This antibody has been reported to activate B cells via engagement of the IgD receptor. The use of anti-IgM as a polyclonal B cell activator is problematic due to interference from high levels of circulating serum IgM. Crossblocking studies suggest that the 10.4.22 antibody recognizes a different epitope from 11-26c. Applications Reported: This 10.4.22 antibody has been reported for use in functional assays. Applications Tested: This 10.4.22 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

This type I transmembrane protein is co-expressed on the surface of mature naive B cells with membrane IgM. IgD also exists as a soluble form in blood serum. Studies have demonstrated that IgD associates with the B cell receptor and participates in mediating signal transduction upon antigen binding.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Mouse IgD
Applications Functional Assay
Classification Monoclonal
Clone 10.4.22
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Ighd
Gene Accession No. P01881
Gene Alias IgD; Igh-5; IGHD; immunoglobulin heavy constant delta
Gene Symbols Ighd
Host Species Mouse
Purification Method Affinity chromatography
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 380797
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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