IGF1R beta chain Mouse anti-Human, Rat, Clone: 3C6A11, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 662831IG150UL

Catalog No. 50-173-6715

Description

This antibody raised against a synthesized polypeptide (CGVLVLRASFDERQPYAH) corresponding to 1332-1348aa of human IGF1R protein recognizes beta chain of IGF1R.

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of maligt cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.

Specifications

• Antigen: IGF1R beta chain
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P08069, P24062
• Gene Symbols: IGF1R
• Immunogen: Peptide
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 3C6A11
• Conjugate: Unconjugated
• Gene: IGF1R
• Gene Alias: CD221, IGF I receptor, IGF1R, IGF1R-Specific, IGFIR, IGFR, JTK13
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 25718, 3480
• Content And Storage: -20°C
• Form: Liquid