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Invitrogen™ IGF1R (CD221) Monoclonal Antibody (1H7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA110854

Catalog No. 01-671-867


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Description

Description

MA1-10854 detects IGF-1 Receptor from human samples. MA1-10854 has been successfully used in Western blot applications. Dilute in PBS or medium which is identical to that used in the assay system. The MA1-10854 immunogen is purified human placental IGF-1 receptors.

IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IGF1R (CD221)
Monoclonal
1.4 mg/mL
PBS with no preservative; pH 7.4
P08069
IGF1R
Purified human placental IGF-1 receptors.
100 μg
Primary
Human
Antibody
IgG1
Western Blot
1H7
Unconjugated
IGF1R
A330103N21Rik; CD221; CD221 antigen; D930020L01; hyft; IGF 1 receptor; IGF 1R; IGF1R; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Mouse
Protein G
RUO
3480
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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