Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ IGF1R (CD221) Monoclonal Antibody (1H7)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA110854
Description
MA1-10854 detects IGF-1 Receptor from human samples. MA1-10854 has been successfully used in Western blot applications. Dilute in PBS or medium which is identical to that used in the assay system. The MA1-10854 immunogen is purified human placental IGF-1 receptors.
IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.
Specifications
IGF1R (CD221) | |
Monoclonal | |
1.4 mg/mL | |
PBS with no preservative; pH 7.4 | |
P08069 | |
IGF1R | |
Purified human placental IGF-1 receptors. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
1H7 | |
Unconjugated | |
IGF1R | |
A330103N21Rik; CD221; CD221 antigen; D930020L01; hyft; IGF 1 receptor; IGF 1R; IGF1R; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2 | |
Mouse | |
Protein G | |
RUO | |
3480 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction