IGF2BP3 Monoclonal Antibody (OTI5G10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811495

Catalog No. 50-168-4082

Description

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some maligcies. IMP-3 is expressed in maligt melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of maligt melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Specifications

• Antigen: IGF2BP3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O00425
• Gene Symbols: IGF2BP3
• Immunogen: Full length human recombit protein of human IGF2BP3 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5G10
• Conjugate: Unconjugated
• Gene: IGF2BP3
• Gene Alias: CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10643
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid