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Invitrogen™ IkB epsilon Polyclonal Antibody
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Catalog No. PIPA597058
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100 μL
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PIPA597058 100 μL
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Catalog No. PIPA597058 Supplier Invitrogen™ Supplier No. PA597058
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSEARKGPDE AEESQYDSGI ESLRSLRSLP ESTSAPASGP SDGSPQPCTH PPGPVKEPQE KEDADGERAD STYGSSSLTY TLSLLGGPEA EDPAPRLPLP HVGALSPQQL EALTYISEDG DTLVHLAVIH EAPAVLLCCL A; Positive Samples: Mouse liver, Mouse thymus; Cellular Location: Cytoplasm.

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).
TRUSTED_SUSTAINABILITY

Specifications

Antigen IkB epsilon
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Nfkbie
Gene Accession No. O54910
Gene Alias ikappaBepsilon; I-kappa-B-epsilon; IkB epsilon; IKBE; IkB-E; IkBepsilon; ikB-epsilon; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; NFKB inhibitor epsilon; NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; Slc35b2; solute carrier family 35, member B2
Gene Symbols Nfkbie
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human NFKBIE (NP_0045472).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18037
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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