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Invitrogen™ IkB zeta Monoclonal Antibody (LK2NAP), eBioscience™

Rat Monoclonal Antibody

Supplier:  Invitrogen™ 14680182

Encompass_Preferred

Catalog No. 50-112-2720


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Description

Description

Description: The LK2NAP monoclonal antibody reacts with mouse IkB zeta (INAP, MAIL). IkBz is a member of the IkB family of cytoplasmic proteins and transcription factors and also shares structural homology with Bcl-3. It is induced in monocytes, macrophages and B cells in response to TLR and IL-1R signaling. In NK cells, IkBz is rapidly upregulated in response to IL-12 and IL-18 and is necessary for production of IFN gamma. In T cells, IkBz is not necessary for IFN gamma and IL-4 production by Th1 and Th2 cells, respectively. However in Th17 cells, IkBz acts in concert with RORa and RORgt to upregulate IL-17A, IL-17F, IL-21, IL-22 and IL-23R expression. Applications Reported: This LK2NAP antibody has been reported for use in western blotting. Applications Tested: This LK2NAP antibody has been tested by western blotting on reduced lysates at > 1 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IkB zeta
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9EST8
NFKBIZ
Affinity chromatography
RUO
80859
4°C
Liquid
Western Blot
LK2NAP
Unconjugated
NFKBIZ
AA408868; FLJ30225; FLJ34463; Ikappa B-zeta variant 3; ikappaBzeta; I-kappa-B-zeta; IkappaB-zeta; IKBZ; ikB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; Mail; molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKB inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; RGD1310834
Rat
100 μg
Primary
Mouse
Antibody
IgG2a κ
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