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IL-1 beta Mouse anti-Human, Biotin, Clone: CRM57, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$118.00 - $312.00

Specifications

Antigen IL-1 beta
Clone CRM57
Target Species Human
Conjugate Biotin
Isotype IgG2b
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-121-47 Non-distribution product as customer accommodation.
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Invitrogen
13701681
50 μg Each for $118.00
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50-121-48 Non-distribution product as customer accommodation.
View Documents
Invitrogen
13701685
500 μg Each for $312.00
Add to cart
 
Description

Description

Description: The CRM57 antibody reacts with human and baboon interleukin-1beta (IL-1beta). IL-1beta is a 17 kDa factor secreted primarily by monocytes. IL-1 has effects on T-helper cells, inducing IL-2 secretion and expression of IL-2 receptors. IL-1 has effects on B cells, promoting cell proliferation and immunoglobulin synthesis. Applications Reported: The CRM57 antibody has been reported for use in ELISA and ELISPOT. Applications Tested: The CRM57 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human interleukin-1 beta (IL-1 beta) in combination with the purified CRM56 (14-7018) for capture and recombit human IL-1 beta (14-8018) as the standard. A suitable range of concentrations of this antibody for use in ELISA detection is 0.25 -1 µg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 µm post-manufacturing filtered.

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

IL-1 beta
Human
IgG2b
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
CRM57
Biotin
ELISA
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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