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Invitrogen™ IL-10 Monoclonal Antibody (16E3)
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Catalog No. ENMM011
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500 μg
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Catalog No. Quantity
ENMM011 500 μg
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Catalog No. ENMM011 Supplier Invitrogen™ Supplier No. MM011
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Description

Rat Monoclonal Antibody

MM011 targets IL-10 in ELISA applications and shows reactivity with mouse samples. The MM011 immunogen is recombinant mouse IL-10. MM011 detects IL-10 which has a predicted molecular weight of approximately 19 kDa. This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified. This product is a Low Endotoxin formulation. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
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Specifications

Antigen IL-10
Applications ELISA, Western Blot
Classification Monoclonal
Clone 16E3
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene IL10
Gene Accession No. P18893
Gene Alias CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Gene Symbols IL10
Host Species Rat
Immunogen Recombinant mouse IL-10.
Purification Method Protein G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16153
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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