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Invitrogen™ IL-12 p70 Monoclonal Antibody (C17-8), Biotin
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Catalog No. ENMM121B
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250 μg
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ENMM121B 250 μg
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Catalog No. ENMM121B Supplier Invitrogen™ Supplier No. MM121B
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Description

Rat Monoclonal Antibody

MM121B targets IL-12 in ELISA, and WB applications and shows reactivity with mouse samples. The MM121B immunogen is recombinant mouse IL-12. MM121B detects IL-12 which has a predicted molecular weight of approximately 22 kDa. The MM121B mouse IL12 antibody (biotinylated conjugate of clone C17-8) has successfully been paired as the detection antibody in a sandwich ELISA with capture antibody MM120 (clone 9A5). Typical dilutions for sandwich ELISA include 1 μg/mL for coating and 0.125 - 0.25 μg/mL for detection. Biotinylated antibody MM121B (clone C17-8) and antibody MM120 (clone 9A5) have successfully been used in combination with recombinant mouse IL12p70 protein SMIL12 in ELISA applications. This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified.

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.
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Specifications

Antigen IL-12 p70
Applications ELISA, Western Blot
Classification Monoclonal
Clone C17-8
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 4% BSA and proprietary Preservative
Gene IL12A
Gene Accession No. P43431, P43432
Gene Alias 20C2; CLMF; CLMF p35; CLMF p40; CLMF2; cytokine; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; Il12; IL-12; Il-12 p35; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL12, subunit p40; Il-12; cytokine; IL12A; IL-12A; IL12A/B; IL12AB; IL12B; Il-12b; IL12P35; IL-12p35; Il12p40; Il-12p40; IL35 subunit; ILN; IMD28; IMD29; Interleukin; interleukin 12 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12 p35 subunit; interleukin 12 p40 subunit precursor; interleukin 12 polypeptide 35; interleukin 12, p35; interleukin 12, p40; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 12p35 subunit precursor; interleukin-12 alpha chain; interleukin-12 alpha p40 subunit; interleukin-12 beta chain; interleukin-12 beta p35 subunit; interleukin-12 p35 subunit; interleukin-12 p35 subunit precursor; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 p40 subunit precursor; Interleukin-12 p70; interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; Ll12a; MGC151228; MGC151232; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; P35; p40
Gene Symbols IL12A, Il12b
Host Species Rat
Immunogen Recombinant mouse IL-12.
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16159, 16160
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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