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IL-13 Monoclonal Antibody (eBio13A), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$3260.00
Specifications
| Antigen | IL-13 |
|---|---|
| Clone | eBio13A |
| Concentration | 1 mg/mL |
| Classification | Monoclonal |
| Conjugate | Functional Grade |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
16-713-338
|
Invitrogen™
16713338 |
5 mg |
Each of 1 for $3,260.00
|
|
|||||
Description
The eBio13A antibody reacts with mouse IL-13. IL-13 is a cytokine produced mainly by Th2 cells, but also by antigen-primed CD8 T cells. IL-13 has a strong involvement in allergic inflammation and parasitic clearing and in cancer models has been shown to have either inhibitory or stimulatory activity depending on the tumor. In humans, IL-13 is found to play a role in isotype switching in B cells. IL-13 is implicating in down modulating macrophage activity, through the reduction of pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, IL-12) Applications Reported: The eBio13A antibody has been reported useful for ELISA and ELISPOT capture, as well as intracellular staining for flow cytometric analysis.
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.Specifications
| IL-13 | |
| 1 mg/mL | |
| Functional Grade | |
| Rat | |
| Mouse | |
| P20109 | |
| IgG1 κ | |
| Affinity Chromatography | |
| Antibody |
| eBio13A | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with no preservative; pH 7.2 | |
| 16163 | |
| Primary | |
| 4°C | |
| Il13 |
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