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Invitrogen™ IL-13 Monoclonal Antibody (PVM13-1), Functional Grade, eBioscience™
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Catalog No. 5014725
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50 μg
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Catalog No. Quantity
50-147-25 50 μg
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Catalog No. 50-147-25 Supplier Invitrogen™ Supplier No. 16713981
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Description

Mouse Monoclonal Antibody

Description: The PVM13-1 antibody reacts with human interleukin-13 (IL-13). IL-13, also known as NC30, is a 12.5 kDa protein secreted by activated T helper cells, CD8^+ T cells, and NK cells. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression and suppression of inflammatory cytokine expression. Applications Reported: The PVM13-1 antibody has been reported for use as the capture antibody in an IL-13 ELISPOT assay or ELISA, as well as for neutralization of IL-13 bioactivity. Applications Tested: The functional grade PVM13-1 antibody has been tested for ELISA and ELISPOT capture and neutralization of IL-13 bioactivity. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
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Specifications

Antigen IL-13
Applications Functional Assay, Immunostaining, Neutralization
Classification Monoclonal
Clone PVM13-1
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Il13
Gene Accession No. P35225
Gene Alias ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600
Gene Symbols Il13
Host Species Mouse
Purification Method Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3596
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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