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Description
Description: The polyclonal antibody reacts with human interleukin-13 (IL-13). IL-13, also known as NC30, is a 12.5 kDa protein secreted by activated T helper cells, CD8^+ T cells, and NK cells. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression and suppression of inflammatory cytokine expression. Applications Reported: The biotinylated anti-human IL-13 polyclonal antibody has been reported for use in ELISA and ELISPOT. Applications Tested: The biotinylated anti-human IL-13 polyclonal antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human IL-13 in combination with the purified PVM13-1 (14-7139) antibody for capture and recombinant human IL-13 (14-8139) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 μg/mL. A standard curve consisting of doubling dilutions of the recombinant cytokine standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
Specifications
| IL-13 | |
| Polyclonal | |
| Biotin | |
| Il13 | |
| ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600 | |
| Rabbit | |
| 50 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| Immunostaining | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P35225 | |
| Il13 | |
| Affinity chromatography | |
| RUO | |
| 3596 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid | |
| Responsibly packaged |
Safety and Handling
WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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