Invitrogen™ IL-2 Monoclonal Antibody (297C16F11)

Catalog No.	Quantity
AHC0722	500 μg

Catalog No. AHC0722 Supplier Invitrogen™ Supplier No. AHC0722

Description

Mouse Monoclonal Antibody

Purity is >95% by SDS-PAGE. Kd: 1.8 x 10^-9 This product can inhibit the binding of IL-2 on p55 receptor.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Specifications

• Antigen: IL-2
• Applications: Dot Blot, Inhibition Assays, Immunohistochemistry, Neutralization
• Classification: Monoclonal
• Clone: 297C16F11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.4
• Gene: IL2
• Gene Accession No.: P60568
• Gene Alias: aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
• Gene Symbols: IL2
• Host Species: Mouse
• Immunogen: Recombinant human IL-2.
• Purification Method: Protein A
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3558
• Target Species: Human
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ

Frequently Asked Questions (FAQs)

What is the neutralizing mechanism of Thermo Fisher Scientific' mouse anti-human IL-2 neutralizing antibody (Cat. No. AHC0722, clone 297C16F11)

Mouse monoclonal anti-IL-2 antibody, AHC0722, neutralizes cytokine activity by blocking an epitope on the IL-2 protein that normally binds to the p55 IL-2 receptor. This neutralizes the activity of the IL-2 protein.