Invitrogen™ IL-2 Monoclonal Antibody (B-G5), Biotin

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ M600B

Catalog No. ENM600B

Description

M600B targets IL-2 in ELISA, and WB applications and shows reactivity with Human samples. The M600B immunogen is recombinant human IL-2. M600B detects IL-2 which has a predicted molecular weight of approximately 15 kDa. The M600B IL2 antibody (biotinylated conjugate of clone BG5) has successfully been paired as the detection antibody in a sandwich ELISA with polyclonal capture antibody P600. Typical dilutions for sandwich ELISA include 1 μg/mL for coating and 0.125 - 0.25 μg/mL for detection. Biotinylated antibody M600B (clone BG5) and antibody P600 have successfully been used in combination with recombinant IL2 protein SIL2 in ELISA applications.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Specifications

• Antigen: IL-2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 4% BSA and proprietary Preservative
• Gene Accession No.: P60568
• Gene Symbols: IL2
• Immunogen: Recombinant human IL-2.
• Quantity: 250 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot
• Clone: B-G5
• Conjugate: Biotin
• Gene: IL2
• Gene Alias: aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
• Host Species: Mouse
• Purification Method: Ion-exchange Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3558
• Content And Storage: -20°C
• Form: Liquid
• Green Features: Responsibly packaged

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov