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Invitrogen™ IL-23 p19 Chimeric Recombinant Human Monoclonal Antibody (mh066)
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Catalog No. PIMA543119
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200 μg
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PIMA543119 200 μg
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Catalog No. PIMA543119 Supplier Invitrogen™ Supplier No. MA543119
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Description

Human Recombinant Monoclonal Antibody

Specificity: Human IL23A and Human IL12B Heterodimer. This product is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The antibody was produced using recombinant antibody technology.

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.
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Specifications

Antigen IL-23 p19 Chimeric
Applications Neutralization
Classification Recombinant Monoclonal
Clone mh066
Concentration 2.25 mg/mL
Conjugate Unconjugated
Formulation arginine, histidine with 120mM NaCl, 0.02% Tween 80 and no preservative
Gene IL23A
Gene Accession No. Q9EQ14, Q9NPF7
Gene Alias il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Gene Symbols IL23A
Host Species Human
Immunogen Recombinant Human IL23A and Mouse IL12B Heterodimer Protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51561, 83430
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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