Invitrogen™ IL-31 Monoclonal Antibody (8-C3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA534912

Catalog No. PIMA534912

Description

Positive Control: Recombinant protein lysate, A431, LOVO, MCF-7, human tonsil tissue, human spleen tissue.

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Specifications

• Antigen: IL-31
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q6EBC2
• Gene Symbols: Il31
• Immunogen: Recombinant protein within Human IL31 aa 1-164.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG3

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 8-C3
• Conjugate: Unconjugated
• Gene: Il31
• Gene Alias: 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 386653
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid