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Invitrogen™ IL-5 Monoclonal Antibody (39D10), Biotin
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Catalog No. ENM550B Shop All Thermo Scientific Products
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ENM550B 250 μg
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Catalog No. ENM550B Supplier Invitrogen™ Supplier No. M550B
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Description

Rat Monoclonal Antibody

M550B targets IL-5 in ELISA, and WB applications and shows reactivity with Human samples. The M550B immunogen is recombinant human IL-5. M550B detects IL-5 which has a predicted molecular weight of approximately 13 kDa. This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified. The M550B IL1b antibody (biotinylated conjugate of clone 39D10) has successfully been paired as the detection antibody in a sandwich ELISA with capture antibody M551 (clone 5A10). Typical dilutions for sandwich ELISA include 1 μg/mL for coating and 0.125 - 0.25 μg/mL for detection. Biotinylated antibody M550B (clone 39D10) and antibody M551 (clone 5A10) have successfully been used in combination with recombinant IL5 protein SIL5 in ELISA applications.

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
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Specifications

Antigen IL-5
Applications ELISA, Western Blot
Classification Monoclonal
Clone 39D10
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 4% BSA and proprietary Preservative
Gene Il5
Gene Accession No. P05113
Gene Alias B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; Eosinophil differentiation factor; IL5; IL-5; ILN; Interleukin; Interleukin 5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); Interleukin5; interleukin-5; T-cell replacing factor; TRF
Gene Symbols Il5
Host Species Rat
Immunogen Recombinant human IL-5.
Purification Method Caprylic acid precipitation
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3567
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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