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  6. Invitrogen™ IL-5 Monoclonal Antibody (JES1-5A10), Biotin, eBioscience™, Invitrogen™ 

Invitrogen™ IL-5 Monoclonal Antibody (JES1-5A10), Biotin, eBioscience™, Invitrogen™
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Catalog No. 5012161
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50-121-61 50 μg
50-121-62 500 μg
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Catalog No. 50-121-61 Supplier Invitrogen™ Supplier No. 13705981
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Description

Rat Monoclonal Antibody

Description: The JES1-5A10 antibody reacts with human interleukin-5 (IL-5), also known as BCDF-alpha and eosinophil differentiation factor (EDF). This 15-20 kDa cytokine is secreted by T cells and exists a homodimer. Applications Reported: JES1-5A10 has been reported for use in detection of human IL-5 by ELISA. Applications Tested: The JES1-5A10 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human Interleukin-5 (IL-5) in combination with the purified TRFK5 (14-7052) antibody for capture and recombinant human IL-5 (14-8059) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 μg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 500 pg/mL - 4 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
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Specifications

Antigen IL-5
Applications ELISA
Classification Monoclonal
Clone JES1-5A10
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Il5
Gene Accession No. P05113
Gene Alias B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; Eosinophil differentiation factor; IL5; IL-5; ILN; Interleukin; Interleukin 5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); Interleukin5; interleukin-5; T-cell replacing factor; TRF
Gene Symbols Il5
Host Species Rat
Purification Method Affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3567
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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