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Invitrogen™ IL-6 Monoclonal Antibody (20F3)
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Catalog No. PIMM600C Shop All Thermo Scientific Products
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500 μg
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Catalog No. Quantity
PIMM600C 500 μg
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Catalog No. PIMM600C Supplier Invitrogen™ Supplier No. MM600C
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Description

Rat Monoclonal Antibody

MM600C targets IL-6 in ELISA, IHC(P), IP, Neu, and WB applications and shows reactivity with mouse samples. The MM600C immunogen is recombinant mouse IL-6. MM600C detects IL-6 which has a predicted molecular weight of approximately 22 kDa. This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
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Specifications

Antigen IL-6
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization, Western Blot
Classification Monoclonal
Clone 20F3
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Il6
Gene Accession No. P08505
Gene Alias B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Gene Symbols Il6
Host Species Rat
Immunogen Recombinant mouse IL-6.
Purification Method Protein G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16193
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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