Invitrogen™ IL-8 (CXCL8) Polyclonal Antibody

Catalog No.	Quantity
AHC0881	100 μg

Catalog No. AHC0881 Supplier Invitrogen™ Supplier No. AHC0881

Description

Rabbit Polyclonal Antibody

Centrifuge vial prior to opening. Reconstitute in sterile water to 0.1-1.0 mg/mL.

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

Specifications

• Antigen: IL-8 (CXCL8)
• Applications: ELISA, Immunohistochemistry, Neutralization, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.2
• Gene: CXCL8
• Gene Accession No.: P10145
• Gene Alias: (Ala-IL-8)77; (Ser-IL-8)72; Alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; AMCF-I; ANX7; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8; C-X-C motif chemokine ligand 8; CXCL8; cytokine 8; emoctakin; GCP/IL-8 protein I; GCP/IL-8 protein II; GCP/IL-8 protein III; GCP/IL-8 protein IV; GCP/IL-8 protein V; GCP/IL-8 protein VI; GCP1; GCP-1; Granulocyte chemotactic protein 1; IL8; IL-8; IL-8(1-77); IL-8(5-77); IL-8(6-77); IL-8(7-77); IL-8(8-77); IL-8(9-77); IL8/NAP1 form I; IL8/NAP1 form II; IL8/NAP1 form III; IL8/NAP1 form IV; IL8/NAP1 form V; IL8/NAP1 form VI; ILN; Interleukin; interleukin 8; Interleukin8; interleukin-8; interleuklin-8 precursor; LECT; LUCT; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF; MDNCF-a; MDNCF-b; MDNCF-c; MONAP; Monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; NAF; NAP1; NAP-1; neutrophil activating peptide 1; neutrophil and T-lymphocyte chemotactic and activating factor; Neutrophil attractant/activation protein 1; neutrophil attractant/activation protein-1; Neutrophil-activating factor; neutrophil-activating peptide 1; Neutrophil-activating protein 1; Permeability factor 1; PF1; Protein 3-10C; RP11-537A6.8; RPF1; small inducible cytokine subfamily B, member 8; SNX; SYNEXIN; T-cell chemotactic factor; tumor necrosis factor-induced gene 1
• Gene Symbols: CXCL8
• Host Species: Rabbit
• Immunogen: E.coliderived Recombinant Human IL-8 (CXCL8) (aa 28-99).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3576
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Frequently Asked Questions (FAQs)

Which antibodies directed to cytokines are suitable for use in immunohistochemistry with paraffin sections?

The following antibodies have been used successfully for IHC with paraffin sections:
Mouse (monoclonal) Anti-Human TGF-?1 (Cat. No. AHG0051), Rat (monoclonal) Anti-Human Interleukin-13 (Cat. No. AHC0132), Rabbit (polyclonal) Anti-Human IL-8 (Cat. No. AHC0881), Rabbit (polyclonal) Anti-Mouse Interferon-? (Cat. No. AMC4034), Goat (polyclonal) Anti-Mouse TNF-? (Cat. No. AMC3012), and Rabbit (polyclonal) Anti-Rat TNF-? (Cat. No. ARC3012).

You can also locate these and other antibodies with our helpful Primary Antibody Selection Guide. This can be accessed by searching "Primary Antibody Selector Tool" on our website. Once you've reached the Selection Guide, you can narrow the search by clicking on your desired links at the top of the Guide.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov