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Invitrogen™ IL17C Polyclonal Antibody
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Catalog No. PIPA579474
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100 μg
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PIPA579474 100 μg
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Catalog No. PIPA579474 Supplier Invitrogen™ Supplier No. PA579474
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL17C
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation Antibody with 0.2mg Na2PO4, 0.9mg NaCl, 4mg trehalose and 0.05mg sodium azide
Gene IL17C
Gene Accession No. Q8K4C5
Gene Alias CX2; cytokine CX2; Il17c; IL-17C; IL-21; Interleukin; interleukin 17C; interleukin-17C; UNQ561/PRO1122
Gene Symbols IL17C
Host Species Rabbit
Immunogen E. coli-derived mouse IL17C recombinant protein (Position: H15-Q194).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 234836, 691516
Target Species Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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