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IL21 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501731690 Shop All Proteintech Group Inc Products
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50-173-1690 150 μL
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Catalog No. 50-173-1690 Supplier Proteintech Group Inc Supplier No. 176251AP150UL
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Description

Rabbit Polyclonal Antibody

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintece by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Specifications

Antigen IL21
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene IL21
Gene Accession No. Q9HBE4
Gene Alias IL 21, IL21, interleukin 21, Za11
Gene Symbols IL21
Host Species Rabbit
Immunogen IL21 Fusion Protein Ag11838
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59067
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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