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Invitrogen™ IL21R Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141412

Catalog No. 01-675-541


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Description

Description

This antibody is predicted to react with mouse samples based on sequence homology. Suggested positive control: Raji whole cell lysate, NIH-3T3 whole cell lysate.

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IL21R
Polyclonal
Unconjugated
Il21r
CD360; IL-21 receptor; Il21r; IL-21R; interleukin 21 receptor; interleukin-21 receptor; LR-beta; lymphocyte receptor beta; MGC10967; NILR; novel cytokine receptor 8; Novel interleukin receptor; NR8; UNQ3121/PRO10273
Rabbit
Protein G
RUO
50615
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9HBE5
Il21r
Synthetic peptides corresponding to residues 65-80 and 505-521 of human IL-21R.
100 μg
Primary
Human
Antibody
IgG
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