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IL31 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501733957 Shop All Proteintech Group Inc Products
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50-173-3957 150 μL
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Catalog No. 50-173-3957 Supplier Proteintech Group Inc Supplier No. 228591AP150UL
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Description

Rabbit Polyclonal Antibody

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Specifications

Antigen IL31
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.26 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene IL31
Gene Accession No. Q6EAL8, Q6EBC2
Gene Alias IL 31, IL31, interleukin 31
Gene Symbols IL31
Host Species Rabbit
Immunogen IL31 Fusion Protein Ag18848
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 386653, 76399
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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