Invitrogen™ IL31RA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120973

Catalog No. PIPA5120973

Description

Positive test controls include: Mouse liver, Mouse heart, Mouse brain, Mouse pancreas. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein. Immunogen sequence: VKPVLGIKRM IQIEWIKPEL APVSSDLKYT LRFRTVNSTS WMEVNFAKNR KDKNQTYNLT GLQPFTEYVI ALRCAVKESK FWSDWSQEKM GMTEEEAPCG LELWRVLKPA EADGRRPVRL LWKKARGAPV LEKTLGYNIW YYPESNTNLT ETMNTTNQQL ELHLGGESFW VSMISYNSLG KSPVATLRIP AIQEKSFQCI EVMQACVAED QLVVKWQSSA LDVNTWMIEW FPDVDSEPTT LSWESVSQAT NWTIQQDKLK PFWCYNISVY PMLHDKVGEP YSIQAYAKEG VPSEGPETKV EN.

IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

Specifications

• Antigen: IL31RA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL31RA
• Gene Alias: class I cytokine receptor; CRL; CRL 3; CRL3; CRL3Glmr; cytokine receptor NR10; cytokine receptor-like 3; GLM R; Glmr; GLM-R; GLM-RMGC125346; GP130 like receptor; gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLMR; hGLM-R; IL 31RA; IL-31 receptor subunit alpha; IL31R subunit alpha; IL-31R subunit alpha; Il31ra; IL-31RA; IL-31RAGPLCRL; IL-31R-alpha; interleukin 31 receptor A; interleukin 31RA; interleukin-31 receptor subunit alpha; MGC125346; mGLM-R; novel cytokine receptor 10; NR10; PLCA 2; PLCA2; PRO21384; soluble type I cytokine receptor CRL3; UNQ6368/PRO21073/PRO21384; ZcytoR17
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 133396, 218624
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8K5B1, Q8NI17
• Gene Symbols: IL31RA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_0012845011).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG