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Invitrogen™ IL5RA Monoclonal Antibody (26815), APC
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Catalog No. PIMA523581
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100 Tests
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Catalog No. Quantity
PIMA523581 100 Tests
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Catalog No. PIMA523581 Supplier Invitrogen™ Supplier No. MA523581
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Description

Mouse Monoclonal Antibody

In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) IL-5 R beta, rhIL-9 R, rhIL-4 R, rmIL-5 R alpha, or rhIL-13 R alpha 1.

Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL5RA
Applications Flow Cytometry
Classification Monoclonal
Clone 26815
Conjugate APC
Formulation Buffered saline solution with ≤ 0.5% BSA and 0.09% sodium azide
Gene IL5RA
Gene Accession No. Q01344
Gene Alias CD125; CD125 antigen; CDw125; HSIL5R3; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; Il5r; IL-5R subunit alpha; Il5ra; IL-5RA; IL-5R-alpha; interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; interleukin-5 receptor subunit alpha
Gene Symbols IL5RA
Host Species Mouse
Immunogen Sf 21-derived recombinant human IL-5R alpha/CD125 Asp21-Arg335.
Purification Method Protein A/G
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3568
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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