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iMAC2, Tocris Bioscience™

Catalog No. 379450
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Catalog No. Quantity
37-945-0 50 mg
37-941-0 10 mg
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Catalog No. 37-945-0 Supplier R&D Systems Supplier No. 3794/50
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Description

Suppressor of mitochondrial apoptosis

Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Chemical Identifiers

CAS 335166-00-2
Molecular Formula C19H22Br2Cl2FN3
Molecular Weight (g/mol) 542.112
InChI Key JWCVUOLQOHIRML-UHFFFAOYSA-N
Synonym imac2, 3,6-dibromo-9-2-fluoro-3-1-piperazinyl propyl-9h-carbazole dihydrochloride, 3,6-dibromo-9-2-fluoro-3-piperazin-1-yl propyl carbazole dihydrochloride
PubChem CID 90488878
IUPAC Name 3,6-dibromo-9-(2-fluoro-3-piperazin-1-ylpropyl)carbazole;dihydrochloride
SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)F.Cl.Cl

Specifications

Quantity 50 mg
Formula Weight 542.11
Percent Purity >98%
Chemical Name or Material iMAC2

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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