Tocris Bioscience™ Imatinib mesylate

Description

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).

Specifications

• Chemical Name or Material: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
• CAS: 220127-57-1
• Synonym: Gleevec, CGP 57148B
• Quantity: 100 mg
• Target: Abl Kinase Inhibitors
• Molecular Formula: C₂₉H₃₁N₇O.CH₄O₃S
• Formula Weight: 589.71
• Purity: >98%