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Tocris Bioscience™ Imatinib mesylate
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Catalog No. 5906100
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100 mg
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59-061-00 100 mg
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Description

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).

Specifications

Chemical Name or Material 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
CAS 220127-57-1
Synonym Gleevec, CGP 57148B
Quantity 100 mg
Target Abl Kinase Inhibitors
Molecular Formula C29H31N7O.CH4O3S
Formula Weight 589.71
Purity >98%
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