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Tocris Bioscience™ Imatinib mesylate

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Quantity:
100 mg
Description
Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 9.823 and 17.689 μM, respectively).
Specifications
Specifications
Chemical Name or Material | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
CAS | 220127-57-1 |
Synonym | Gleevec, CGP 57148B |
Quantity | 100 mg |
Target | Abl Kinase Inhibitors |
Molecular Formula | C29H31N7O.CH4O3S |
Formula Weight | 589.71 |
Purity | >98% |
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