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Tocris Bioscience™ IMD 0354
GREENER_CHOICE

Catalog No. 261150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of IKKβ

Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. Also antagonist at P2X1, P2X4 and P2X7 receptors (IC50 values are 19, 156 and 175 nM respectively). Inhibits platelet aggregation induced by collegen in vitro.

Chemical Identifiers

CAS 978-62-1
Molecular Formula C15H8ClF6NO2

Specifications

Quantity 50 mg
Formula Weight 383.67
Purity >99%
Molecular Weight (g/mol) 383.67
Chemical Name or Material IMD 0354

Safety and Handling

Recommended Storage Store at +4°C
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