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Importin 11/IPO11 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A304810AT

Encompass_Preferred

Catalog No. 50-156-8740


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
Specifications

Specifications

Importin 11/IPO11
Polyclonal
Unconjugated
IPO11
RanBP11
Rabbit
Antigen affinity chromatography
RUO
51194
4° C
Liquid
Immunoprecipitation
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Q9UI26
IPO11
Between 825 and 875
10 μL
Primary
Human
Antibody
IgG
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