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Tocris Bioscience™ IN 1130
GREENER_CHOICE

Catalog No. 60165
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5mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective inhibitor of TGF-βRI

IN 1130 is a potent and selective inhibitor of TGF-β type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38α. Attenuates TGFβ/Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

Specifications

Chemical Name or Material 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide
CAS 868612-83-3
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C25H20N6O
Formula Weight Observed MW: 420.47
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