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INCENP Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7144002
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50-157-1412 10 μL
50-157-1411 100 μL
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Catalog No. 50-157-1412 Supplier Bethyl Laboratories, Inc Supplier No. IHC00060T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and ′passenger,′ or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB, CENPC1, and CENPD. The term ′passenger proteins′ encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994). These include CENPE; MCAK; KID; cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin. The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999).

Specifications

Antigen INCENP
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene INCENP
Gene Accession No. Q9NQS7
Gene Alias binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; inner centromere protein; inner centromere protein INCENP
Gene Symbols INCENP
Host Species Rabbit
Immunogen Between 325 and 400
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3619
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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