Indole-5-carboxylic acid, 98%

Description

CAS: 1670-81-1 | C9H6NO2 | 160.15 g/mol

Indole-5-carboxylic acid is the suitable reagent used to study the intermolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films. Also used as reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators, synthesis of indirubin derivatives and amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Indole-5-carboxylic acid is the suitable reagent used to study the intermolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films. Also used as reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators, synthesis of indirubin derivatives and amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway.

Solubility
Soluble in ethanol (50 mg/ml), dimethyl sulfoxide and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Specifications

Chemical Identifiers

• CAS: 1670-81-1
• Molecular Formula: C9H6NO2
• Molecular Weight (g/mol): 160.15
• MDL Number: MFCD00005678
• InChI Key: IENZCGNHSIMFJE-UHFFFAOYSA-M
• Synonym: indole-5-carboxylic acid, 5-carboxyindole, 5-indolecarboxylic acid, indole-5-carboxylic aicd, pubchem1694, 5-carboxy-1h-indole, indole-5-carboxylicacid, indol-5-carboxylic acid, 5-indole carboxylic acid, indole 5-carboxylic acid
• PubChem CID: 74280
• IUPAC Name: 1H-indole-5-carboxylic acid
• SMILES: [O-]C(=O)C1=CC=C2NC=CC2=C1

• Melting Point: 208°C to 212°C
• Quantity: 1 g
• Beilstein: 124391
• Solubility Information: Soluble in ethanol (50mg/ml),dimethyl sulfoxide and methanol.
• Formula Weight: 161.16
• Percent Purity: 98%
• Chemical Name or Material: Indole-5-carboxylic acid

Safety and Handling

Hazard Category	H302+H312-H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	216-799-6
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only