Thermo Scientific Chemicals Indomethacin

Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C₁₉H₁₆ClNO₄ | 357.79 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release

• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics

• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions

• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

Specifications

Chemical Identifiers

• CAS: 53-86-1
• Molecular Formula: C₁₉H₁₆ClNO₄
• Molecular Weight (g/mol): 357.79
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• PubChem CID: 3715
• ChEBI: CHEBI:49662
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

• Melting Point: 155.0°C
• Loss on Drying: 0.5% max. (100°C, 2 h, 5 mm Hg)
• Infrared Spectrum: Authentic
• Quantity: 5 g
• Formula Weight: 357.79
• Percent Purity: ≥97.5% (HPLC)
• Chemical Name or Material: Indomethacin

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement Fatal if swallowed. May cause an allergic skin reaction. May damage fertility. May damage the unborn child.
Precautionary Statement	GHS P Statement IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Wear protective gloves/protective clothing. IF ON SKIN: Wash with plenty of soap and water. Obtain special instructions before use
EINECSNumber	200-186-5

SDS

RUO – Research Use Only