Indomethacin, 98%

Catalog No.	Quantity
AAA1991022	100 g
AAA1991006	5 g
AAA1991014	25 g

Catalog No. AAA1991022 Supplier Thermo Scientific Chemicals Supplier No. A1991022

Description

CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Notes
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 53-86-1
• Molecular Formula: C19H16ClNO4
• Molecular Weight (g/mol): 357.79
• MDL Number: MFCD00057095
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• PubChem CID: 3715
• ChEBI: CHEBI:49662
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

• Melting Point: 158°C to 161°C
• Assay Percent Range: 0.98
• Quantity: 100 g
• UN Number: UN2811
• Beilstein: 497341
• Sensitivity: Light sensitive
• Merck Index: 14,4968
• Solubility Information: Soluble in acetone (40mg/mL- clear,yellow solution),ethanol (20mg/mL),ether,castor oil; Soluble in chloroform (50mg/mL- clear,yellow,extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
• Formula Weight: 357.8
• Percent Purity: 98%
• Chemical Name or Material: Indomethacin

Safety and Handling

Hazard Category	H300-H317-H360FD
Hazard Statement	GHS H Statement H300-H341 Fatal if swallowed. Suspected of causing genetic defects.
Precautionary Statement	P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c
DOTInformation	Hazard Class: 6.1; Packaging Group: II
EINECSNumber	200-186-5
RTECSNumber	NL3500000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only