Indomethacin, 99+%

Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

Specifications

Chemical Identifiers

• CAS: 53-86-1
• Molecular Formula: C19H16ClNO4
• Molecular Weight (g/mol): 357.79
• MDL Number: MFCD00057095
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• PubChem CID: 3715
• ChEBI: CHEBI:49662
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

• Melting Point: 158°C to 161°C
• Color: White
• Quantity: 1 g
• UN Number: UN2811
• Beilstein: 497341
• Sensitivity: Light sensitive
• Merck Index: 14,4968
• Solubility Information: Soluble in ethanol and dimethyl sulfoxide.
• Formula Weight: 357.8
• Percent Purity: ≥99%
• Physical Form: Powder
• Chemical Name or Material: Indomethacin

Safety and Handling

Hazard Category	H300-H317-H360FD
Hazard Statement	GHS H Statement H300-H341 Fatal if swallowed. Suspected of causing genetic defects.
Precautionary Statement	P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c
DOTInformation	Hazard Class: 6.1; Packaging Group: II
EINECSNumber	200-186-5
RTECSNumber	NL3500000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only