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Invitrogen™ INSR Monoclonal Antibody (18-44)
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Catalog No. 01671874
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100 μg
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Catalog No. Quantity
01-671-874 100 μg
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Catalog No. 01-671-874 Supplier Invitrogen™ Supplier No. MA110865
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Mouse Monoclonal Antibody

MA1-10865 detects Insulin Receptor from human samples. Low cross-reactivity with bovine and rabbit samples. MA1-10865 has been successfully used in Western blot and immunoprecipitation applications. The MA1-10865 immunogen is human placental insulin receptor.

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INSR
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 18-44
Concentration 0.41 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene INSR
Gene Accession No. P06213
Gene Alias 4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B
Gene Symbols INSR
Host Species Mouse
Immunogen human placental insulin receptor.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3643
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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